Human herpes virus 8-negative primary effusion lymphoma with BCL6 rearrangement in a patient with idiopathic CD4 positive T-lymphocytopenia

Haematologica. 2008 Jan;93(1):e21-3. doi: 10.3324/haematol.12085.

Abstract

Primary effusion lymphoma (PEL) was initially designated as a body-cavity-based lymphoma and recognized as a distinct clinical entity without a contiguous tumor mass. PEL was first reported in patients with acquired immunodeficiency syndrome (AIDS) and the distinctive feature of PEL originally reported as a B-cell neoplasm characterized by infection of the tumor cells by human herpes virus 8 (HHV-8). However, there have recently been several reports of PEL in patients without human immunodeficiency virus (HIV) or HHV-8 infection.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / pharmacology
  • CD4 Antigens / biosynthesis*
  • DNA-Binding Proteins / genetics*
  • Dyspnea / diagnosis
  • Gene Rearrangement*
  • HIV Infections / diagnosis
  • Herpesvirus 8, Human / genetics*
  • Herpesvirus 8, Human / metabolism
  • Humans
  • Immunophenotyping
  • Lymphoma, Primary Effusion / complications
  • Lymphoma, Primary Effusion / genetics*
  • Lymphoma, Primary Effusion / therapy
  • Lymphopenia / complications
  • Lymphopenia / therapy*
  • Male
  • Pericardial Effusion
  • Proto-Oncogene Proteins c-bcl-6
  • T-Lymphocytes / metabolism*

Substances

  • Antineoplastic Agents
  • BCL6 protein, human
  • CD4 Antigens
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins c-bcl-6