Abstract
Chromosomal translocations involving BCL6 were detected in 7 out of 392 cases of MALT lymphoma by interphase fluorescence in situ hybridisation with a BCL6 break-apart probe. With the exception of BCL6 protein expression in 2 of the 7 cases, these BCL6 translocation-positive MALT lymphomas were histologically and immunophenotypically identical to classic cases.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Gene Expression Regulation, Neoplastic*
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Humans
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Immunohistochemistry
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Immunophenotyping
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In Situ Hybridization, Fluorescence
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Lymphoma, B-Cell, Marginal Zone / genetics*
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Oligonucleotide Array Sequence Analysis
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Proto-Oncogene Proteins c-bcl-6
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RNA, Messenger / metabolism
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Translocation, Genetic*
Substances
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BCL6 protein, human
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DNA-Binding Proteins
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Proto-Oncogene Proteins c-bcl-6
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RNA, Messenger