Association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women

Shan Kang; Xi-Wa Zhao; Na Wang; Shu-Cheng Chen; Rong-Miao Zhou; Yan Li

doi:10.1016/j.fertnstert.2007.09.068

Association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women

Fertil Steril. 2008 Nov;90(5):2023-9. doi: 10.1016/j.fertnstert.2007.09.068. Epub 2008 Jan 4.

Authors

Shan Kang¹, Xi-Wa Zhao, Na Wang, Shu-Cheng Chen, Rong-Miao Zhou, Yan Li

Affiliation

¹ Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.

PMID: 18177649
DOI: 10.1016/j.fertnstert.2007.09.068

Abstract

We investigated whether three polymorphisms in the matrix metalloproteinase-2 (MMP-2; -1306C-->T and -735C-->T) and tissue inhibitor of metalloproteinase-2 (TIMP-2; -418G-->C) genes were related to the risk of endometriosis in reproductive-aged women with and without endometriosis. Our results indicate that the TIMP-2 -418C/C homozygote may be a protective factor against the development of endometriosis in North Chinese women.

MeSH terms

Adult
Asian People / genetics*
Case-Control Studies
China / epidemiology
Endometriosis / enzymology
Endometriosis / ethnology
Endometriosis / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Linkage Disequilibrium
Matrix Metalloproteinase 2 / genetics*
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic
Risk Assessment
Risk Factors
Tissue Inhibitor of Metalloproteinase-2 / genetics*
Young Adult

Substances

Tissue Inhibitor of Metalloproteinase-2
MMP2 protein, human
Matrix Metalloproteinase 2