Abstract
In this commentary, we accent the accumulating evidence for motor impairment as a common feature of early Alzheimer's disease (AD) pathology. In addition, we summarize the state of knowledge on this phenotype in experimental mouse models, expressing AD-associated genes like tau or amyloid precursor protein.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / complications*
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Alzheimer Disease / genetics
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Alzheimer Disease / pathology
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Amyloid beta-Protein Precursor / genetics
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Amyloid beta-Protein Precursor / metabolism
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Animals
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Axons / pathology
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Disease Models, Animal*
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Humans
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Mice*
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Mice, Transgenic
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Movement Disorders / etiology*
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tau Proteins / genetics
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tau Proteins / metabolism
Substances
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Amyloid beta-Protein Precursor
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tau Proteins