Comparison of the cardioprotective effects of cardos and losartan in rats with experimental chronic cardiac insufficiency

I N Tiurenkov; A N Nazvanova; N G Tchepurina; I A Kheyfets; J L Dugina; A V Martyushev-Poklad; S A Sergeeva; O I Epstein

doi:10.1007/s10517-007-0149-0

Comparison of the cardioprotective effects of cardos and losartan in rats with experimental chronic cardiac insufficiency

Bull Exp Biol Med. 2007 Apr;143(4):434-6. doi: 10.1007/s10517-007-0149-0.

Authors

I N Tiurenkov¹, A N Nazvanova, N G Tchepurina, I A Kheyfets, J L Dugina, A V Martyushev-Poklad, S A Sergeeva, O I Epstein

Affiliation

¹ Volgograd State Medical University, Federal Agency for Health Protection and Social Development.

PMID: 18214293
DOI: 10.1007/s10517-007-0149-0

Abstract

Cardioprotective effect of cardos was revealed on rat model of experimental cardiac insufficiency induced by injectionof isoproterenol. Cardos improved exercise tolerance, cardiac output, and stroke volume. Cardos administered for 28 days was no less effective than losartan.

Publication types

Comparative Study

MeSH terms

Angiotensin II Type 1 Receptor Blockers / administration & dosage
Angiotensin II Type 1 Receptor Blockers / pharmacology
Animals
Antibodies / immunology
Antibodies / pharmacology*
Cardiotonic Agents / administration & dosage
Cardiotonic Agents / pharmacology*
Chronic Disease
Disease Models, Animal
Female
Heart Failure / chemically induced
Heart Failure / drug therapy*
Isoproterenol / toxicity
Losartan / administration & dosage
Losartan / pharmacology*
Male
Peptide Fragments / immunology
Rats
Rats, Wistar
Receptor, Angiotensin, Type 1 / chemistry
Receptor, Angiotensin, Type 1 / immunology

Substances

Angiotensin II Type 1 Receptor Blockers
Antibodies
Cardiotonic Agents
Peptide Fragments
Receptor, Angiotensin, Type 1
Losartan
Isoproterenol