Abstract
To explore a novel adipokine, we screened adipocyte differentiation-related gene and found that TIG2/chemerin was strongly induced during the adipocyte differentiation. Chemerin was secreted by the mature 3T3-L1 adipocytes and expressed abundantly in adipose tissue in vivo as recently described. Intriguingly, the expression of chemerin was differently regulated in the liver and adipose tissue in db/db mice. In addition, serum chemerin concentration was decreased in db/db mice. Chemerin and its receptor/ChemR23 were expressed in mature adipocytes, suggesting its function in autocrine/paracrine fashion. Finally, chemerin potentiated insulin-stimulated glucose uptake concomitant with enhanced insulin signaling in the 3T3-L1 adipocytes. These data establish that chemerin is a novel adipokine that regulates adipocyte function.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3-L1 Cells
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Adipocytes / cytology
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Adipocytes / drug effects
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Adipocytes / metabolism*
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Adipose Tissue / drug effects
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Adipose Tissue / metabolism
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Animals
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Antibody Specificity / drug effects
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COS Cells
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Cell Differentiation / drug effects
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Chemokines
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Chemotactic Factors / genetics
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Chemotactic Factors / metabolism*
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Chemotactic Factors / pharmacology
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Chlorocebus aethiops
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Culture Media
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Gene Expression Profiling
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Gene Expression Regulation / drug effects
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Glucose / metabolism*
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Humans
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Insulin / metabolism*
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Intercellular Signaling Peptides and Proteins / genetics
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Intercellular Signaling Peptides and Proteins / metabolism*
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Intercellular Signaling Peptides and Proteins / pharmacology
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Liver / drug effects
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Liver / metabolism
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Male
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Mice
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Mice, Inbred C57BL
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Signal Transduction* / drug effects
Substances
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Chemokines
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Chemotactic Factors
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Culture Media
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Insulin
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Intercellular Signaling Peptides and Proteins
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chemerin protein, mouse
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Glucose