Effects of alpha1-acid glycoprotein on free radical oxidation processes in experimental liver failure

Bull Exp Biol Med. 2007 Jul;144(1):26-8. doi: 10.1007/s10517-007-0244-2.
[Article in English, Russian]

Abstract

The effects of alpha1-acid glycoprotein (2 intraperitoneal injections in a total dose of 300 mg/kg) on free radical oxidation during liver failure were studied in 53 outbred rats. On day 3 of liver failure, glycoprotein reduced plasma concentrations of free radical oxidation products, elevated the antioxidant potential of the plasma and liver and kidney homogenates, and restored functional reserve and capacity of leukocytes to generation of oxygen radicals.

MeSH terms

  • Animals
  • Carbon Tetrachloride Poisoning / metabolism
  • Free Radicals / metabolism*
  • Hydrogen Peroxide / blood*
  • Liver Failure / metabolism*
  • Luminescence
  • Male
  • Orosomucoid / pharmacology*
  • Oxidation-Reduction
  • Rats

Substances

  • Free Radicals
  • Orosomucoid
  • Hydrogen Peroxide