Expression of peripheral benzodiazepine receptor, PCNA, and caspase-3 in cells of skin melanoma and squamous cell carcinoma

T G Ruksha; A B Salmina; V D Sokolov; T V Maksimova; Yu A Anisimov

doi:10.1007/s10517-007-0259-8

Expression of peripheral benzodiazepine receptor, PCNA, and caspase-3 in cells of skin melanoma and squamous cell carcinoma

Bull Exp Biol Med. 2007 Jul;144(1):77-9. doi: 10.1007/s10517-007-0259-8.

[Article in English, Russian]

Authors

T G Ruksha¹, A B Salmina, V D Sokolov, T V Maksimova, Yu A Anisimov

Affiliation

¹ Department of Biochemistry with a Course of Medical Chemistry, Krasnoyarsk State Medical Academy, Federal Agency for Public Health and Social Development. tatyana_ruksha@mail.ru

PMID: 18256758
DOI: 10.1007/s10517-007-0259-8

Abstract

The intensity of cell proliferation and apoptosis and expression peripheral benzodiazepine receptor were studied in skin biopsy specimens from patients with squamous cell carcinoma and melanoma of the skin. Sharp inhibition of apoptosis and changes in the levels of cell proliferation in tumor cells were paralleled by decreased expression of peripheral benzodiazepine receptor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Carcinoma, Squamous Cell / metabolism*
Caspase 3 / biosynthesis*
Cell Proliferation
Gene Expression Regulation, Neoplastic
Humans
Melanoma / metabolism*
Proliferating Cell Nuclear Antigen / biosynthesis*
Receptors, GABA-A / biosynthesis*
Skin / metabolism
Skin Neoplasms / metabolism*

Substances

Proliferating Cell Nuclear Antigen
Receptors, GABA-A
Caspase 3