Abstract
We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.
MeSH terms
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Adolescent
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Alleles
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Anemia, Sickle Cell / blood
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Anemia, Sickle Cell / genetics*
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Anemia, Sickle Cell / immunology
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Arterial Occlusive Diseases / blood
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Arterial Occlusive Diseases / genetics*
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Arterial Occlusive Diseases / immunology
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Child
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Constriction, Pathologic / blood*
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Endothelium, Vascular / pathology
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Erythrocytes, Abnormal / pathology
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Female
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Genetic Predisposition to Disease
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HLA-DQ Antigens / genetics*
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HLA-DQ beta-Chains
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HLA-DR Antigens / genetics*
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HLA-DRB1 Chains
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Haplotypes
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Humans
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Ischemia / blood*
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Male
Substances
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HLA-DQ Antigens
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HLA-DQ beta-Chains
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HLA-DQB1 antigen
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HLA-DR Antigens
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HLA-DRB1 Chains
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HLA-DRB1*11:01:01 antigen