Abstract
For the first time, the multilocus approach by the set-association method has been applied for the analysis of a cluster of five genes [tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), IL-8, IL-1alpha and IL-10] involved in the brain neuroinflammatory pathway in Parkinson's disease (PD), in a well-defined group of 197 PD patients and 173 control subjects from Spain. Set-association analysis did not reveal an independent or an interactive effect of these inflammatory genes on the PD risk.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Brain / metabolism
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Female
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Genotype
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Humans
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Inflammation / complications
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Inflammation / genetics*
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Inflammation / metabolism
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Interleukin-10 / genetics
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Interleukin-1alpha / genetics
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Interleukin-6 / genetics
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Interleukin-8 / genetics
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Male
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Middle Aged
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Parkinson Disease / etiology*
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Parkinson Disease / genetics*
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Parkinson Disease / metabolism
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Parkinson Disease / pathology
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Polymorphism, Single Nucleotide / genetics*
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Spain / epidemiology
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Tumor Necrosis Factor-alpha / genetics
Substances
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Interleukin-1alpha
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Interleukin-6
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Interleukin-8
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Tumor Necrosis Factor-alpha
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Interleukin-10