Serum procalcitonin (PCT) as a negative screening test for colonic ischemia after open abdominal aortic surgery

Eur J Vasc Endovasc Surg. 2008 Jun;35(6):694-7. doi: 10.1016/j.ejvs.2007.11.014. Epub 2008 Mar 4.

Abstract

Background and aim: We assessed serum procalcitonin (PCT) as a screening test for early detection of ischemic colitis.

Patients and methods: Ninety-three patients (81 men and 12 women) undergoing elective aortic surgery were enrolled in this study. Their mean age was 70.3+/-8.1 years old. Serum procalcitonin was measured postoperatively.

Results: Four patients suffered from colon ischemia. Based on a cut off value of serum PCT>/=2.0 ng/ml, fourteen patients had a false positive but none had a false negative result. Sensitivity was 100%, and specificity was 83.9% in detecting ischemic colitis. Negative predictive vale was 100%.

Conclusion: Serum PCT is a non-invasive test that has a high negative predictive vale in ruling out colon ischemia after aortic surgery.

Publication types

  • Evaluation Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aortic Diseases / blood
  • Aortic Diseases / surgery*
  • Biomarkers / blood
  • Calcitonin / blood*
  • Calcitonin Gene-Related Peptide
  • Colitis, Ischemic / blood
  • Colitis, Ischemic / diagnosis*
  • Colitis, Ischemic / etiology
  • Early Diagnosis
  • Elective Surgical Procedures
  • Female
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Protein Precursors / blood*
  • Sensitivity and Specificity
  • Treatment Outcome
  • Vascular Surgical Procedures / adverse effects*

Substances

  • Biomarkers
  • CALCA protein, human
  • Protein Precursors
  • Calcitonin
  • Calcitonin Gene-Related Peptide