Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors

Cell Metab. 2008 Mar;7(3):187-8. doi: 10.1016/j.cmet.2008.02.002.

Abstract

Cannabinoid signaling by CB1 receptors drives fibrogenesis and fat accumulation in liver. A report in this issue of Cell Metabolism (Jeong et al., 2008) now links hepatic stellate cells, a resident liver fibrogenic cell type, to the generation of steatosis through production of the endocannabinoid 2-arachidonoylglycerol (2-AG) after ethanol feeding, leading to paracrine stimulation of hepatocyte CB1 receptors.

Publication types

  • Comment

MeSH terms

  • Animals
  • Arachidonic Acids / metabolism
  • Cannabinoid Receptor Modulators / metabolism*
  • Carnitine O-Palmitoyltransferase / metabolism
  • Cells, Cultured
  • Diet, Fat-Restricted
  • Disease Models, Animal
  • Endocannabinoids
  • Ethanol
  • Fatty Acid Synthases / metabolism
  • Fatty Acids / metabolism
  • Fatty Liver, Alcoholic / etiology
  • Fatty Liver, Alcoholic / genetics
  • Fatty Liver, Alcoholic / metabolism*
  • Fatty Liver, Alcoholic / pathology
  • Fatty Liver, Alcoholic / prevention & control
  • Glycerides / metabolism
  • Hepatocytes / metabolism
  • Humans
  • Lipogenesis* / drug effects
  • Lipogenesis* / genetics
  • Lipoprotein Lipase / metabolism
  • Liver / drug effects
  • Liver / enzymology
  • Liver / metabolism*
  • Liver / pathology
  • Mice
  • Oxidation-Reduction
  • Paracrine Communication* / drug effects
  • Paracrine Communication* / genetics
  • Piperidines / pharmacology
  • Pyrazoles / pharmacology
  • Receptor, Cannabinoid, CB1 / antagonists & inhibitors
  • Receptor, Cannabinoid, CB1 / genetics
  • Receptor, Cannabinoid, CB1 / metabolism*
  • Rimonabant
  • Sterol Regulatory Element Binding Protein 1 / metabolism
  • Up-Regulation

Substances

  • Arachidonic Acids
  • Cannabinoid Receptor Modulators
  • Endocannabinoids
  • Fatty Acids
  • Glycerides
  • Piperidines
  • Pyrazoles
  • Receptor, Cannabinoid, CB1
  • Srebf1 protein, mouse
  • Sterol Regulatory Element Binding Protein 1
  • Ethanol
  • glyceryl 2-arachidonate
  • Carnitine O-Palmitoyltransferase
  • Fatty Acid Synthases
  • Lipoprotein Lipase
  • Rimonabant