Abstract
Cannabinoid signaling by CB1 receptors drives fibrogenesis and fat accumulation in liver. A report in this issue of Cell Metabolism (Jeong et al., 2008) now links hepatic stellate cells, a resident liver fibrogenic cell type, to the generation of steatosis through production of the endocannabinoid 2-arachidonoylglycerol (2-AG) after ethanol feeding, leading to paracrine stimulation of hepatocyte CB1 receptors.
MeSH terms
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Animals
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Arachidonic Acids / metabolism
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Cannabinoid Receptor Modulators / metabolism*
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Carnitine O-Palmitoyltransferase / metabolism
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Cells, Cultured
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Diet, Fat-Restricted
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Disease Models, Animal
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Endocannabinoids
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Ethanol
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Fatty Acid Synthases / metabolism
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Fatty Acids / metabolism
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Fatty Liver, Alcoholic / etiology
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Fatty Liver, Alcoholic / genetics
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Fatty Liver, Alcoholic / metabolism*
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Fatty Liver, Alcoholic / pathology
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Fatty Liver, Alcoholic / prevention & control
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Glycerides / metabolism
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Hepatocytes / metabolism
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Humans
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Lipogenesis* / drug effects
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Lipogenesis* / genetics
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Lipoprotein Lipase / metabolism
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Liver / drug effects
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Liver / enzymology
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Liver / metabolism*
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Liver / pathology
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Mice
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Oxidation-Reduction
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Paracrine Communication* / drug effects
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Paracrine Communication* / genetics
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Piperidines / pharmacology
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Pyrazoles / pharmacology
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Receptor, Cannabinoid, CB1 / antagonists & inhibitors
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Receptor, Cannabinoid, CB1 / genetics
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Receptor, Cannabinoid, CB1 / metabolism*
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Rimonabant
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Sterol Regulatory Element Binding Protein 1 / metabolism
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Up-Regulation
Substances
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Arachidonic Acids
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Cannabinoid Receptor Modulators
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Endocannabinoids
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Fatty Acids
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Glycerides
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Piperidines
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Pyrazoles
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Receptor, Cannabinoid, CB1
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Srebf1 protein, mouse
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Sterol Regulatory Element Binding Protein 1
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Ethanol
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glyceryl 2-arachidonate
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Carnitine O-Palmitoyltransferase
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Fatty Acid Synthases
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Lipoprotein Lipase
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Rimonabant