Abstract
Recently genetic variation in the DAPK1 and ABCA2 genes has been reported to be associated with late- and early-onset Alzheimer's disease (AD), respectively. We examined the most significant two single-nucleotide polymorphisms (SNPs) in DAPK1 in a large case-control cohort of late-onset subjects and matched controls and one of the most significant SNPs in ABCA2 in a small set of early-onset subjects as well. We did not detect associations with AD for any variation.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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ATP-Binding Cassette Transporters / genetics*
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Adaptor Proteins, Signal Transducing
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Alzheimer Disease / genetics*
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Apoptosis Regulatory Proteins / genetics*
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Autophagy-Related Proteins
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Calcium-Calmodulin-Dependent Protein Kinases / genetics*
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Carrier Proteins / genetics
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Case-Control Studies
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Cell Cycle Proteins / genetics
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Chromosomes, Human, Pair 9 / genetics*
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Cohort Studies
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Death-Associated Protein Kinases
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Gene Frequency
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Genotype
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Humans
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Polymorphism, Single Nucleotide / genetics*
Substances
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ABCA2 protein, human
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ATP-Binding Cassette Transporters
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Adaptor Proteins, Signal Transducing
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Apoptosis Regulatory Proteins
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Autophagy-Related Proteins
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Carrier Proteins
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Cell Cycle Proteins
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UBQLN1 protein, human
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DAPK1 protein, human
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Death-Associated Protein Kinases
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Calcium-Calmodulin-Dependent Protein Kinases