Tat-SIRT1 tango

Mol Cell. 2008 Mar 14;29(5):539-40. doi: 10.1016/j.molcel.2008.02.007.

Abstract

In a recent issue of Cell Host & Microbe, Kwon et al. (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation.

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology
  • Animals
  • HIV-1 / genetics
  • HIV-1 / metabolism
  • Humans
  • Lymphocyte Activation
  • Mice
  • NF-kappa B / metabolism
  • Sirtuin 1
  • Sirtuins / genetics
  • Sirtuins / metabolism*
  • T-Lymphocytes / immunology
  • Transcription, Genetic
  • tat Gene Products, Human Immunodeficiency Virus / genetics
  • tat Gene Products, Human Immunodeficiency Virus / metabolism*

Substances

  • NF-kappa B
  • tat Gene Products, Human Immunodeficiency Virus
  • SIRT1 protein, human
  • Sirtuin 1
  • Sirtuins