Effect of protein convertase subtilisin/kexin type 9 (PCSK9) 46L gene polymorphism on LDL cholesterol concentration in a Polish adult population

Grazyna Kostrzewa; Grazyna Broda; Paweł Kurjata; Walerian Piotrowski; Rafal Ploski

doi:10.1016/j.ymgme.2008.02.003

Effect of protein convertase subtilisin/kexin type 9 (PCSK9) 46L gene polymorphism on LDL cholesterol concentration in a Polish adult population

Mol Genet Metab. 2008 Jun;94(2):259-62. doi: 10.1016/j.ymgme.2008.02.003. Epub 2008 Mar 14.

Authors

Grazyna Kostrzewa¹, Grazyna Broda, Paweł Kurjata, Walerian Piotrowski, Rafal Ploski

Affiliation

¹ Department of Medical Genetics, Medical University of Warsaw, ul Oczki 1, 02-007 Warsaw, Poland.

PMID: 18343176
DOI: 10.1016/j.ymgme.2008.02.003

Abstract

The purpose was to study the effect of PCSK9 46L on cholesterol concentration and cardiovascular morbidity. By comparing 176 carriers with 6618 non-carriers identified through a cross-sectional population study (WOBASZ) we confirmed the LDL lowering effect of PCSK9 46L and demonstrated that it increases with the concentration of LDL. We noted that PCSK9 46L was associated with tendency for protection from myocardial infarction but not stroke suggesting a difference in the effect on susceptibility to these disorders.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Blood / metabolism
Cholesterol, LDL / blood*
Cross-Sectional Studies
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Myocardial Infarction / diagnosis
Myocardial Infarction / genetics*
Myocardial Infarction / mortality
Polymorphism, Genetic*
Proprotein Convertase 9
Proprotein Convertases
Serine Endopeptidases / genetics*
Stroke / diagnosis
Stroke / genetics*
Stroke / mortality
White People / genetics*

Substances

Cholesterol, LDL
PCSK9 protein, human
Proprotein Convertase 9
Proprotein Convertases
Serine Endopeptidases