CTLA-4 and multiple sclerosis: the A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population

J Neuroimmunol. 2008 May 30;196(1-2):139-42. doi: 10.1016/j.jneuroim.2008.02.001. Epub 2008 Apr 2.

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P<0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / genetics*
  • Australia / epidemiology
  • CTLA-4 Antigen
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • HLA-DR Antigens
  • Humans
  • Multiple Sclerosis / genetics*
  • Polymorphism, Single Nucleotide / genetics*

Substances

  • Antigens, CD
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • HLA-DR Antigens