Protein S deficiency, epileptic seizures, sagittal sinus thrombosis and hemorrhagic infarction after ingestion of dimenhydrinate

Nezih Oktar; Tayfun Dalbasti

Protein S deficiency, epileptic seizures, sagittal sinus thrombosis and hemorrhagic infarction after ingestion of dimenhydrinate

Turk Neurosurg. 2008 Jan;18(1):85-8.

Authors

Nezih Oktar¹, Tayfun Dalbasti

Affiliation

¹ Ege University School of Medicine, Neurosurgery Department Izmir, Turkey. nezih.oktar@edge.edu.tr

PMID: 18382986

Abstract

Congenital protein S deficiency is associated with an increased risk of venous thrombosis. A14-year-old boy presented with epileptic seizures and thrombosis of the superior sagittal sinus and frontal hemorrhagic venous infarction after ingestion of 50 mg of dimenhydrinate, an antiemetic drug. The patient was found to be heterozygous for the factor V Leiden mutation and had a functional protein S deficiency. He recovered completely within a month after conservative treatment. Dimenhydrinate may have disrupted a subclinical pre-existing condition in this case.

Publication types

Case Reports

MeSH terms

Adolescent
Antiemetics / adverse effects*
Cerebral Hemorrhage / chemically induced
Cerebral Hemorrhage / pathology
Cerebral Infarction / chemically induced*
Cerebral Infarction / pathology
Dimenhydrinate / adverse effects*
Epilepsy / chemically induced*
Factor V / genetics
Humans
Magnetic Resonance Imaging
Male
Protein S Deficiency / complications*
Protein S Deficiency / genetics
Sagittal Sinus Thrombosis / chemically induced*
Sagittal Sinus Thrombosis / pathology
Venous Thrombosis / chemically induced
Venous Thrombosis / pathology

Substances

Antiemetics
factor V Leiden
Factor V
Dimenhydrinate