Blastic mantle cell lymphoma with a Burkitt translocation

Leuk Lymphoma. 2008 Apr;49(4):740-50. doi: 10.1080/10428190701852024.

Abstract

MYC gene rearrangements are observed as a genetic change in the blastoid variant of mantle cell lymphoma (MCL). We present two patients, one had 30% atypical lymphocytes with Burkitt-like morphology in the peripheral blood and the other had 30% blasts in the bone marrow. Both had a CCND1/IGH and an MYC rearrangement by cytogenetics and FISH. The immunophenotype was CD5+[one was a weak positive], CD10+, CD20+, CCND1+, >90% Ki-67 proliferation fraction and CD23 negative. The diagnosis was blastic MCL with Burkitt features. These cases, along with the reported cases, distinguish an aggressive category of a blastic MCL with a poor prognosis that probably requires Burkitt therapy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Burkitt Lymphoma / genetics
  • Chromosomes, Human, Pair 11
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 8
  • Gene Rearrangement
  • Humans
  • In Situ Hybridization, Fluorescence
  • Lymphoma, Mantle-Cell / genetics*
  • Male
  • Translocation, Genetic*