Testis-determining factor and Y-linked sex reversal

Curr Opin Genet Dev. 1991 Jun;1(1):30-3. doi: 10.1016/0959-437x(91)80037-m.

Abstract

A gene named SRY, isolated last year from the sex-determining region of the human Y chromosome, satisfies many of the criteria expected of the testis-determining factor gene. Mutations in SRY have been found in XY females, strongly implicating SRY as the testis-determining gene.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics*
  • Disorders of Sex Development*
  • Female
  • Genetic Linkage
  • Humans
  • Kruppel-Like Transcription Factors
  • Male
  • Mice / genetics
  • Mutation
  • Nuclear Proteins*
  • Sex Determination Analysis*
  • Sex-Determining Region Y Protein
  • Transcription Factors*
  • Y Chromosome*

Substances

  • DNA-Binding Proteins
  • Kruppel-Like Transcription Factors
  • Nuclear Proteins
  • SRY protein, human
  • Sex-Determining Region Y Protein
  • Sry protein, mouse
  • Transcription Factors
  • ZFY protein, human
  • zinc finger protein, X-linked