Abstract
A gene named SRY, isolated last year from the sex-determining region of the human Y chromosome, satisfies many of the criteria expected of the testis-determining factor gene. Mutations in SRY have been found in XY females, strongly implicating SRY as the testis-determining gene.
MeSH terms
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Animals
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DNA-Binding Proteins / genetics*
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Disorders of Sex Development*
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Female
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Genetic Linkage
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Humans
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Kruppel-Like Transcription Factors
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Male
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Mice / genetics
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Mutation
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Nuclear Proteins*
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Sex Determination Analysis*
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Sex-Determining Region Y Protein
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Transcription Factors*
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Y Chromosome*
Substances
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DNA-Binding Proteins
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Kruppel-Like Transcription Factors
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Nuclear Proteins
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SRY protein, human
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Sex-Determining Region Y Protein
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Sry protein, mouse
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Transcription Factors
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ZFY protein, human
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zinc finger protein, X-linked