[Clinical significance of carriage of rare variants of connexin-26 genetic polymorphism in gastric cancer]

V M Sedov; A N Iaitskiĭ; E D Mozgovoĭ; N M Volkov; F V Moiseenko; M V Dubina; V A Krutovskikh

[Clinical significance of carriage of rare variants of connexin-26 genetic polymorphism in gastric cancer]

Vestn Khir Im I I Grek. 2007;166(6):11-4.

[Article in Russian]

Authors

V M Sedov, A N Iaitskiĭ, E D Mozgovoĭ, N M Volkov, F V Moiseenko, M V Dubina, V A Krutovskikh

PMID: 18411733

Abstract

The authors present first results of investigations of the connexin-26 gene in DNA obtained from peripheral blood of 55 patients operated on for gastric cancer. Gastric cancer patients were found to have carriage of the Cx 26 gene that was reliably associated with the invasive ability of the tumor. Change of the connexin-26 gene in gastric cancer is evidence of an important role of intercellular gap junctions in the arising and development of gastric cancer.

Publication types

Comparative Study

MeSH terms

Biomarkers, Tumor / blood
Biomarkers, Tumor / genetics
Biopsy
Connexin 26
Connexins / blood
Connexins / genetics*
DNA, Neoplasm / genetics*
Endoscopy, Gastrointestinal
Genetic Predisposition to Disease / genetics*
Humans
Polymerase Chain Reaction
Polymorphism, Genetic*
Prognosis
Risk Factors
Stomach Neoplasms / blood
Stomach Neoplasms / diagnosis
Stomach Neoplasms / genetics*

Substances

Biomarkers, Tumor
Connexins
DNA, Neoplasm
Connexin 26