Abstract
Polymorphism of GSTT1 and GSTM1 variant genes of phase II biotransformation of xenobiotics was studied in 181 patients with lung cancer. Null genotype frequency in cancer patients was higher than in healthy subjects. It was still higher in metastatic cancer disseminated to the regional lymph nodes as compared with localized tumor.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Aged
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Biomarkers, Tumor / genetics*
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Case-Control Studies
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Female
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Genotype
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Glutathione Transferase / genetics*
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Humans
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Lung Neoplasms / genetics*
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Male
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Middle Aged
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Polymorphism, Genetic*
Substances
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Biomarkers, Tumor
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glutathione S-transferase T1
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Glutathione Transferase
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glutathione S-transferase M1