Abstract
PITX3 is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons, the gene of which is disrupted in a putative mouse model for Parkinson's disease (PD). The A-allele of a HapMap tagging SNP (rs4919621) that was genotyped in a population of 361 PD patients, 69 of which had early onset, and in 333 controls, was significantly more common in PD patients with an early age of onset when compared either to controls (p=0.002) or to PD patients with late onset (p=0.001). In contrast, a previous finding suggesting a SNP (rs3758549) in the putative promoter region of the PITX3 gene to be associated with PD could not be replicated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Age of Onset
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Brain Chemistry / genetics*
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Cell Survival / genetics
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DNA Mutational Analysis
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Dopamine / metabolism
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Female
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Gene Frequency
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Genetic Markers / genetics
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Genetic Predisposition to Disease / genetics*
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Genetic Testing
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Genotype
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Homeodomain Proteins / genetics*
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Humans
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Male
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Middle Aged
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Nerve Degeneration / genetics
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Nerve Degeneration / metabolism
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Neurons / metabolism
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Parkinson Disease / genetics*
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Parkinson Disease / metabolism
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Polymorphism, Genetic / genetics*
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Promoter Regions, Genetic / genetics
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Substantia Nigra / metabolism
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Transcription Factors / genetics*
Substances
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Genetic Markers
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Homeodomain Proteins
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Transcription Factors
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homeobox protein PITX3
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Dopamine