Abstract
We determined the IL-6 -174 G>C single nucleotide polymorphism, IL-6 mRNA expression in subcutaneous adipose tissue (SAT) and IL-6 plasma levels in HIV-1-infected patients with and without lipodystrophy and uninfected controls. HIV-1-infected patients had a greater prevalence of the IL-6 -174 C/C genotype and the C allele, higher SAT IL-6 mRNA expression and plasma IL-6 levels than controls. The IL-6 -174 G>C genotype distribution and allele frequencies, SAT IL-6 mRNA expression and IL-6 plasma levels were non-significantly different between HIV-1-infected patients with and without lipodystrophy.
Publication types
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Comparative Study
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Alleles
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Anti-HIV Agents / therapeutic use
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Antiretroviral Therapy, Highly Active
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Case-Control Studies
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Cross-Sectional Studies
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Female
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Gene Frequency
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Genotype
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HIV Infections / drug therapy
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HIV Infections / immunology*
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HIV-1*
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HIV-Associated Lipodystrophy Syndrome / drug therapy
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HIV-Associated Lipodystrophy Syndrome / immunology*
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Humans
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Interleukin-6 / blood
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Interleukin-6 / genetics*
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Male
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Middle Aged
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Polymorphism, Single Nucleotide*
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RNA, Messenger / analysis
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Subcutaneous Fat / immunology
Substances
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Anti-HIV Agents
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Interleukin-6
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RNA, Messenger