Interleukin-11, interleukin-1beta, interleukin-12 and the pathogenesis of inflammatory periodontal diseases

J Clin Periodontol. 2008 May;35(5):365-70. doi: 10.1111/j.1600-051X.2008.01212.x.

Abstract

Objectives: The balance between pro-inflammatory and anti-inflammatory cytokines may be crucial for determining the immunopathology of gingivitis (G) and periodontitis. This study aimed to analyse interleukin-1beta (IL-1beta), IL-11 and IL-12 levels in gingival crevicular fluid (GCF) of patients with G and chronic periodontitis (CP).

Material and methods: Fourty subjects including 12 CP, 14 G and 14 controls (C) were enrolled. GCF samples were collected from six maxillary sites per patient and analysed for IL-1beta, IL-11 and IL-12 by an enzyme-linked immunosorbent assay.

Results: Significantly lower concentrations of IL-11 were detected in CP compared with both G and C groups (p<0.05). The CP group had a significantly higher total amount of IL-12 and IL-1beta compared with the C group (p<0.05). The IL-11:IL-1beta cytokine ratio was higher in both G and C groups compared with the CP group. The IL-11:IL-1beta ratio became progressively lower with increasing probing depth (p<0.01).

Conclusions: Our data showed that IL-11 levels are significantly decreased in GCF from sites with periodontitis compared with G and healthy sites. Because of the possible preventive effect of IL-11 on inflammation, IL-11 may be an important factor in the therapeutic modulation of periodontal disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Chronic Disease
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gingival Crevicular Fluid / chemistry
  • Gingivitis / immunology*
  • Gingivitis / metabolism
  • Humans
  • Interleukin-11 / analysis
  • Interleukin-11 / biosynthesis*
  • Interleukin-12 / analysis
  • Interleukin-12 / biosynthesis*
  • Interleukin-1beta / analysis
  • Interleukin-1beta / biosynthesis*
  • Male
  • Periodontitis / immunology*
  • Periodontitis / metabolism

Substances

  • Interleukin-11
  • Interleukin-1beta
  • Interleukin-12