Abstract
The role of CD26 in human T cell biology is puzzling. Despite being extensively characterized, it has been called 'a moonlighting protein' since it has multifunctional effects, but a definitive native ligand has not been identified. We summarize the current knowledge on the molecular mechanisms of CD26-mediated T cell costimulation and immune regulation. Work identifying a ligand for CD26 and elucidating the proximal signaling events associated with CD26-mediated T cell costimulation is also described. Finally, we discuss the involvement of CD26 in various pathophysiologic states as well as its suitability as a potential therapeutic target in selected immune diseases.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autoimmune Diseases / therapy
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CARD Signaling Adaptor Proteins / genetics
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CARD Signaling Adaptor Proteins / immunology
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CARD Signaling Adaptor Proteins / metabolism
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Caveolins / genetics
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Caveolins / metabolism
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Cell Proliferation
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Chemokine CCL5 / genetics
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Chemokine CCL5 / immunology
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Chemokine CCL5 / metabolism
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Dipeptidyl Peptidase 4 / chemistry
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Dipeptidyl Peptidase 4 / immunology*
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Dipeptidyl Peptidase 4 / metabolism
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Dipeptidyl Peptidase 4 / therapeutic use
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Guanylate Cyclase / genetics
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Guanylate Cyclase / immunology
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Guanylate Cyclase / metabolism
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Humans
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Lymphocyte Activation / immunology
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PDZ Domains / immunology
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Protein Binding / immunology
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Receptors, Antigen, T-Cell / metabolism
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Signal Transduction / genetics
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Signal Transduction / immunology*
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
Substances
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CARD Signaling Adaptor Proteins
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Caveolins
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Chemokine CCL5
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Receptors, Antigen, T-Cell
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Dipeptidyl Peptidase 4
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CARD11 protein, human
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Guanylate Cyclase