Abstract
Heparin-Binding Epidermal Growth Factor (HB-EGF) is growth factor member of EGF family that stimulate differentiation and growth. HB-EGF was initially identified as a secreted product of human macrophage-like cells, it is sinthetized as a transmembrana protein; proHB-EGF; that is shed by specific metalloproteases, releasing soluble growth factor(sHB-EGF). It exerts biological activity trough activation of the EGFR. sHB-EGF is implicated in diverse biological processes: angiogenesis, shin wound, blastocysts implantation, atherosclerosis, tumor formation moreover it acts as the Diphtheria Toxin (DT) receptor. HB-EGF It's an important molecule because could be a novel targeting for cancer and atherosclerosis therapy.
MeSH terms
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Animals
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Atherosclerosis / drug therapy
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Atherosclerosis / physiopathology
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Cell Transformation, Neoplastic
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Drug Resistance / physiology
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Embryo Implantation / physiology
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ErbB Receptors / physiology
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Heparin-binding EGF-like Growth Factor
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Humans
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Intercellular Signaling Peptides and Proteins / chemistry
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Intercellular Signaling Peptides and Proteins / physiology*
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Intercellular Signaling Peptides and Proteins / therapeutic use
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Mice
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Mitosis / physiology
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Neoplasm Metastasis
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Neovascularization, Physiologic / physiology
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Protein Structure, Tertiary
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Rats
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Receptor, ErbB-4
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Regeneration / physiology
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Wound Healing / physiology
Substances
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HBEGF protein, human
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Hbegf protein, mouse
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Hbegf protein, rat
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Heparin-binding EGF-like Growth Factor
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Intercellular Signaling Peptides and Proteins
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ERBB4 protein, human
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ErbB Receptors
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Erbb4 protein, mouse
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Erbb4 protein, rat
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Receptor, ErbB-4