A pilot case-control association study of cytokine polymorphisms in Brazilian women presenting with HPV-related cervical lesions

Eur J Obstet Gynecol Reprod Biol. 2008 Oct;140(2):241-4. doi: 10.1016/j.ejogrb.2008.04.007. Epub 2008 May 27.

Abstract

Objective and study design: A case-control study was conducted on 42 Brazilian women presenting with human papilloma virus (HPV) infection and cervical lesion and 87 HPV-negative women to evaluate single nucleotide polymorphisms observed in TNF-alpha, TGF-beta, IL-10, IL-6, and IFN-gamma genes.

Results and conclusion: No significant association was observed on the cytokine polymorphisms analyzed in this series. Larger studies using cytokine polymorphisms may be useful for providing further information regarding their influence or not in HPV-related cervical lesions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brazil
  • Case-Control Studies
  • Cytokines / genetics*
  • Female
  • Humans
  • Middle Aged
  • Papillomavirus Infections / complications*
  • Papillomavirus Infections / virology
  • Pilot Projects
  • Polymorphism, Single Nucleotide
  • Uterine Cervical Dysplasia / genetics*
  • Uterine Cervical Dysplasia / virology
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / virology
  • Young Adult

Substances

  • Cytokines