A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia

Cancer Genet Cytogenet. 2008 Jun;183(2):105-8. doi: 10.1016/j.cancergencyto.2008.02.005.

Abstract

We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulting from a t(9;22)(p24;q11) translocation as the sole cytogenetic abnormality. The BCR-JAK2 fusion gene has the same breakpoint in BCR as is found in the BCR/ABL p210. The chimeric gene is the result of a reciprocal translocation between chromosomes 9 and 22, which implies a double break on chromosome 9; this has allowed generating an in-frame fusion transcript. Previously, BCR-JAK2 rearrangement was observed in a single case with atypical chronic myelogenous leukemia (CML), but in that case the breakpoint in the BCR was different.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Base Sequence
  • Chromosomes, Human, Pair 22*
  • Chromosomes, Human, Pair 9*
  • DNA Primers
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Janus Kinase 2 / genetics*
  • Leukemia, Myeloid, Acute / genetics*
  • Proto-Oncogene Proteins c-bcr / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Translocation, Genetic*

Substances

  • DNA Primers
  • JAK2 protein, human
  • Janus Kinase 2
  • Proto-Oncogene Proteins c-bcr