First-generation epidermal growth factor receptor tyrosine kinase inhibitors in EGFR mutation: positive non-small cell lung cancer patients

J Thorac Oncol. 2008 Jun;3(6 Suppl 2):S143-5. doi: 10.1097/JTO.0b013e318174e981.

Abstract

Small molecule tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR) are important agents in the treatment of non-small cell lung cancer (NSCLC) and have enhanced activity in the subpopulation of patients with NSCLC who harbor somatic activating mutations of the EGFR gene. This review summarizes the data describing the use of EGFR tyrosine kinase inhibitors in a genotype-directed population of NSCLC patients with EGFR mutations and discusses areas that require further study.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage
  • Carcinoma, Non-Small-Cell Lung / drug therapy*
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Carcinoma, Non-Small-Cell Lung / mortality
  • DNA Mutational Analysis
  • ErbB Receptors / antagonists & inhibitors*
  • Female
  • Genes, erbB-1 / drug effects
  • Genetic Predisposition to Disease
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / mortality
  • Male
  • Mutation
  • Prognosis
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Risk Assessment
  • Survival Analysis
  • Treatment Outcome

Substances

  • Angiogenesis Inhibitors
  • ErbB Receptors
  • Protein-Tyrosine Kinases