Abstract
Tight control of the tyrosine kinase activity of c-Src is critical for regulating its oncogenic potential. In a recent issue of Molecular Cell, Oneyama et al. (2008a) report that the membrane-bound adaptor protein Cbp (also known as PAG) can suppress c-Src-mediated cell transformation and tumorigenesis by binding and sequestering c-Src within lipid rafts. Cbp is also a raft-associated binding partner for Csk, a negative regulator of c-Src. However, the authors show that Cbp-mediated Src suppression is Csk independent. These findings suggest that Cbp is a tumor suppressor whose expression is downregulated during Src-driven cancer progression.
MeSH terms
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Animals
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CSK Tyrosine-Protein Kinase
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Cell Proliferation
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism*
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Cell Transformation, Neoplastic / pathology
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Fibroblasts / enzymology
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Fibroblasts / metabolism*
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Fibroblasts / pathology
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Gene Expression Regulation, Neoplastic
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Humans
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Membrane Microdomains / metabolism
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Mice
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Mice, Knockout
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Phosphoproteins / genetics
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Phosphoproteins / metabolism*
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Protein Transport
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Protein-Tyrosine Kinases / genetics
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Protein-Tyrosine Kinases / metabolism
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Signal Transduction
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Tumor Suppressor Proteins*
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src-Family Kinases / genetics
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src-Family Kinases / metabolism*
Substances
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Membrane Proteins
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Pag1 protein, mouse
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Phosphoproteins
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Tumor Suppressor Proteins
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Protein-Tyrosine Kinases
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CSK Tyrosine-Protein Kinase
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src-Family Kinases
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CSK protein, human