Diffuse cerebral infarct associated with factor V Leiden and prothrombin 20210A mutations in a patient with tetralogy of Fallot

Tansu Sipahi; Selmin Karademir; Ayça Kuybulu; Nejat Akar

doi:10.1177/1076029608319883

Diffuse cerebral infarct associated with factor V Leiden and prothrombin 20210A mutations in a patient with tetralogy of Fallot

Clin Appl Thromb Hemost. 2009 Dec;15(6):705-7. doi: 10.1177/1076029608319883. Epub 2008 Jun 11.

Authors

Tansu Sipahi¹, Selmin Karademir, Ayça Kuybulu, Nejat Akar

Affiliation

¹ Department of Pediatric Hematology, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey. tansusipahi@hotmail.com

PMID: 18550588
DOI: 10.1177/1076029608319883

Abstract

A 2-year-old girl with tetralogy of Fallot presented with diffuse cranial infarct after cardiac angiography. Heterozygosity for factor V Leiden and prothrombin 20210A mutations were detected. The authors suggest that if thrombosis develops in patients with congenital heart disease, genetic risk factors should be evaluated.

Publication types

Case Reports

MeSH terms

Child, Preschool
Factor V / genetics*
Female
Genetic Predisposition to Disease
Heparin, Low-Molecular-Weight
Humans
Mutation*
Prothrombin / genetics
Stroke / drug therapy
Stroke / etiology
Stroke / genetics*
Tetralogy of Fallot / complications*
Warfarin

Substances

Heparin, Low-Molecular-Weight
factor V Leiden
Warfarin
Factor V
Prothrombin