Abstract
SORL1 is an element of the amyloid precursor protein processing pathway and is therefore a good candidate for affecting Alzheimer's disease (AD) risk. Indeed, there have been reports of associations between variation in SORL1 and AD risk. We examined six statistically significant single-nucleotide polymorphisms from the initial observation in a large Caucasian American case-controls cohort (1000 late-onset AD [LOAD] cases and 1000 older controls). Analysis of allele, genotype and haplotype frequencies revealed no association with LOAD risk in our cohort.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Aged
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Alleles
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Alzheimer Disease / diagnosis
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Alzheimer Disease / ethnology
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Alzheimer Disease / genetics*
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Case-Control Studies
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Chi-Square Distribution
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Cohort Studies
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Female
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Gene Frequency
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Genetic Predisposition to Disease / ethnology
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Genetic Predisposition to Disease / genetics
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Genetic Testing / methods
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Genetic Testing / statistics & numerical data
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Genetic Variation
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Genotype
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Haplotypes
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Humans
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LDL-Receptor Related Proteins / genetics*
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Male
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Membrane Transport Proteins / genetics*
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Polymorphism, Single Nucleotide*
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Risk Factors
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United States / epidemiology
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White People / genetics
Substances
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LDL-Receptor Related Proteins
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Membrane Transport Proteins
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SORL1 protein, human