No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population

Branko Aleksic; Masashi Ikeda; Ryoko Ishihara; Shinichi Saito; Toshiya Inada; Nakao Iwata; Norio Ozaki

doi:10.1007/s10038-008-0318-7

No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population

J Hum Genet. 2008;53(9):863-866. doi: 10.1007/s10038-008-0318-7. Epub 2008 Jul 5.

Authors

Branko Aleksic^{1

2

3}, Masashi Ikeda^{4

5}, Ryoko Ishihara^{6

5}, Shinichi Saito^{6

5}, Toshiya Inada⁷, Nakao Iwata^{4

5}, Norio Ozaki^{6

5}

Affiliations

¹ Department of Psychiatry, Graduate School of Medicine, Nagoya University, Showa-ku, Tsurumai-Cho, 65, Nagoya, Aichi, 466-8550, Japan. branko@med.nagoya-u.ac.jp.
² Department of Psychiatry, Graduate School of Medicine, Fujita Health University, Aichi, Japan. branko@med.nagoya-u.ac.jp.
³ CREST, Japan Science and Technology Agency, Saitama, 332-0012, Japan. branko@med.nagoya-u.ac.jp.
⁴ Department of Psychiatry, Graduate School of Medicine, Fujita Health University, Aichi, Japan.
⁵ CREST, Japan Science and Technology Agency, Saitama, 332-0012, Japan.
⁶ Department of Psychiatry, Graduate School of Medicine, Nagoya University, Showa-ku, Tsurumai-Cho, 65, Nagoya, Aichi, 466-8550, Japan.
⁷ Seiwa Hospital, Institute of Neuropsychiatry, Tokyo, Japan.

PMID: 18604471
DOI: 10.1007/s10038-008-0318-7

Abstract

PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Gene Frequency
Genetic Testing
Genetics, Population
Humans
Japan
Male
Middle Aged
Myelin Proteolipid Protein / genetics*
Myelin Proteolipid Protein / metabolism
Oligodendroglia / metabolism
Polymorphism, Single Nucleotide
Schizophrenia / genetics*

Substances

Myelin Proteolipid Protein
PLP1 protein, human