Abstract
Umbilical cord matrix stem (UCMS) cells that were engineered to express interferon-beta (IFN-beta) were transplanted weekly for three weeks into MDA 231 breast cancer xenografts bearing SCID mice in combination with 5-fluorouracil (5-FU). The UCMS cells were found within lung tumors but not in other tissues. Although both treatments significantly reduced MDA 231 tumor area in the SCID mouse lungs, the combined treatment resulted in a greater reduction in tumor area than by either treatment used alone. These results indicate that a combination treatment of UCMS-IFN-beta cells and 5-FU is a potentially effective therapeutic procedure for breast cancer.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimetabolites, Antineoplastic / pharmacology*
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Apoptosis / drug effects
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Breast Neoplasms / surgery
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Breast Neoplasms / therapy*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Cells, Cultured
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Chemotherapy, Adjuvant
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Cord Blood Stem Cell Transplantation*
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Culture Media, Conditioned / metabolism
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Female
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Fetal Stem Cells / metabolism*
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Fluorouracil / pharmacology*
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Genetic Therapy / methods*
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Humans
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Interferon-beta / genetics
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Interferon-beta / metabolism*
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Lung Neoplasms / metabolism
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Lung Neoplasms / secondary
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Lung Neoplasms / surgery
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Lung Neoplasms / therapy*
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Mice
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Mice, SCID
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Time Factors
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Transduction, Genetic
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Xenograft Model Antitumor Assays
Substances
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Antimetabolites, Antineoplastic
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Culture Media, Conditioned
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Interferon-beta
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Fluorouracil