The role of interleukin-10 promoter polymorphisms in primary Sjogren's syndrome

Scand J Rheumatol. 2008 Jul-Aug;37(4):293-9. doi: 10.1080/03009740801910353.

Abstract

Objective: To determine the impact of a broad spectrum of different polymorphisms within the interleukin-10 (IL-10) promoter gene on disease susceptibility to primary Sjogren's syndrome (pSS), clinical manifestations, and autoantibody production.

Methods: We genotyped 111 unrelated German Caucasian patients with pSS and 145 healthy controls for the single nucleotide polymorphisms (SNPs) at positions -2849, -2776, -2769, -2763, -1349, -1082, -851, -819, -657, and -592 and for the microsatellites IL10.R and IL10.G. Allele and haplotype distributions were compared between patients and controls and between subgroups of patients with different clinical and laboratory findings.

Results: We found no significant differences in the allele or haplotype frequencies between pSS patients and healthy controls. After Bonferroni correction we found a significant association of the ACC haplotype (at the -1082, -819, and -592 loci) with immunoglobulin (Ig)A antibodies to anti-alpha-fodrin.

Conclusion: Overall we found no associations of IL-10 promoter polymorphisms with the susceptibility to pSS in our cohort. The finding that the production of IgA anti-alpha-fodrin antibodies is associated with polymorphisms within the IL-10 promoter region suggests a genetic contribution to the generation of these antibodies.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Autoantibodies / genetics*
  • Autoantibodies / immunology
  • Carrier Proteins / immunology*
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Immunoglobulin A / genetics
  • Immunoglobulin A / immunology
  • Interleukin-10 / genetics*
  • Male
  • Microfilament Proteins / immunology*
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Promoter Regions, Genetic*
  • Sjogren's Syndrome / genetics*

Substances

  • Autoantibodies
  • Carrier Proteins
  • IL10 protein, human
  • Immunoglobulin A
  • Microfilament Proteins
  • fodrin
  • Interleukin-10