Pharmacogenetic study of 5,10-methylenetetrahydrofolate reductase C677T and thymidylate synthase 3R/2R gene polymorphisms and methotrexate-related toxicity in Chinese Han patients with inflammatory arthritis

Ann Rheum Dis. 2008 Aug;67(8):1193-4. doi: 10.1136/ard.2007.085266.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adult
  • Arthritis, Reactive / drug therapy
  • Arthritis, Reactive / genetics
  • Asian People
  • Female
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Methotrexate / adverse effects*
  • Methotrexate / therapeutic use
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
  • Middle Aged
  • Polymorphism, Genetic*
  • Thymidylate Synthase / genetics*

Substances

  • Immunosuppressive Agents
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Thymidylate Synthase
  • Methotrexate