Congenital Ewing sarcoma in retroperitoneum with multiple metastases

Yusuke Saito; Akinobu Matsuzaki; Aiko Suminoe; Yuhki Koga; Hiroaki Kurata; Yoshinao Oda; Masazumi Tsuneyoshi; Toshiro Hara

doi:10.1002/pbc.21678

Congenital Ewing sarcoma in retroperitoneum with multiple metastases

Pediatr Blood Cancer. 2008 Nov;51(5):698-701. doi: 10.1002/pbc.21678.

Authors

Yusuke Saito¹, Akinobu Matsuzaki, Aiko Suminoe, Yuhki Koga, Hiroaki Kurata, Yoshinao Oda, Masazumi Tsuneyoshi, Toshiro Hara

Affiliation

¹ Department of Pediatrics, Graduate School of Medical sciences, Kyushu University, Fukuoka, Japan.

PMID: 18623202
DOI: 10.1002/pbc.21678

Abstract

A 7-day-old Japanese female showed the absence of spontaneous movement in her both legs. MRI revealed tumors in the retroperitoneum invading into the spinal canal, the left cerebral hemisphere and the right eyeball. Histological examination of retroperitoneal tumor revealed the sheets of undifferentiated small round cells with hyperchromatic nuclei and scanty cytoplasm. EWS-FLI1 fusion gene was detected by RT-PCR, indicating Ewing sarcoma. She received chemo-radiotherapy and survived for 2 years and 10 months despite the multiple metastases at initial presentation.

Publication types

Case Reports

MeSH terms

Brain Neoplasms / secondary
Eye Neoplasms / secondary
Female
Humans
Infant, Newborn
Oncogene Proteins, Fusion / genetics
Proto-Oncogene Protein c-fli-1
RNA-Binding Protein EWS
Retroperitoneal Neoplasms / congenital*
Retroperitoneal Neoplasms / genetics
Retroperitoneal Neoplasms / secondary*
Reverse Transcriptase Polymerase Chain Reaction
Sarcoma, Ewing / congenital*
Sarcoma, Ewing / genetics
Sarcoma, Ewing / pathology*
Transcription Factors / genetics

Substances

EWS-FLI fusion protein
Oncogene Proteins, Fusion
Proto-Oncogene Protein c-fli-1
RNA-Binding Protein EWS
Transcription Factors