The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia

HIV Med. 2008 Oct;9(8):677-80. doi: 10.1111/j.1468-1293.2008.00614.x. Epub 2008 Jul 8.

Abstract

Objectives: Host genetic factors implicated in AIDS dementia complex (ADC) were studied.

Methods: DNA from ADC patients (n=56), unselected HIV-seropositive patients (n=112, 171, 185 and 204) and HIV-seronegative controls (n=204, 60, 60, 96 and 624) were typed for polymorphic loci in genes encoding tumour necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-12 and Apolipoprotein E (ApoE). Diagnosis of ADC was based on neurological symptoms, signs and neuroimaging findings with other causes of dementia excluded. Patients selected had ADC stage > or =1 and CD4 counts of <500 cells/microL.

Results: Allele 2 of TNFA-308 was more common in ADC patients compared to HIV-positive or HIV-negative controls (P=0.005, 0.024). No other differences between ADC patients and control groups were significant. Meta-analyses confirmed these results.

Conclusions: This study suggests that TNFA-308 allele 2 or an allele in linkage disequilibrium with this locus influences ADC.

Publication types

  • Comparative Study

MeSH terms

  • AIDS Dementia Complex / genetics*
  • AIDS Dementia Complex / immunology
  • Adolescent
  • Adult
  • Apolipoproteins E / genetics*
  • Case-Control Studies
  • Gene Expression Regulation, Viral
  • HIV Infections / immunology*
  • HIV-1*
  • Humans
  • Interleukin-1alpha / genetics
  • Interleukin-1beta / genetics
  • Linkage Disequilibrium
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Genetic*
  • Risk
  • Tumor Necrosis Factor-alpha / genetics*
  • Young Adult

Substances

  • Apolipoproteins E
  • Interleukin-1alpha
  • Interleukin-1beta
  • Tumor Necrosis Factor-alpha