Influence of Lys656Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2

D A de Luis; M Gonzalez Sagrado; R Aller; O Izaola; R Conde

doi:10.1016/j.diabres.2008.06.002

Influence of Lys656Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2

Diabetes Res Clin Pract. 2008 Sep;81(3):e9-e11. doi: 10.1016/j.diabres.2008.06.002. Epub 2008 Jul 15.

Authors

D A de Luis¹, M Gonzalez Sagrado, R Aller, O Izaola, R Conde

Affiliation

¹ Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. Dadluis@yahoo.es

PMID: 18632178
DOI: 10.1016/j.diabres.2008.06.002

Abstract

This is a descriptive study in diabetic patients. Mutant type patient (39%) (Lys656/Asn656 or Asn656/Asn656) group had higher fat mass, HOMA, CRP and leptin than wild type. Adiponectin levels were lower in mutant type group than wild type (61%) (Lys656/Lys656).

MeSH terms

Amino Acid Substitution*
Asparagine
Body Mass Index
Cytokines / blood
Diabetes Mellitus, Type 2 / blood
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / genetics*
Humans
Insulin Resistance / genetics*
Lysine
Obesity / complications
Obesity / genetics
Polymorphism, Genetic*
Receptors, Leptin / genetics*

Substances

Cytokines
Receptors, Leptin
Asparagine
Lysine