Abstract
Polymorphisms in genes involved in vitamin E uptake, distribution, metabolism, and molecular action may be important determinants for the protective effects of vitamin E supplementation. The haptoglobin 2-2 polymorphism is associated with increased production of oxygen free radicals and reduces levels of vitamin E and C; the consequent elevated risk for cardiovascular disease can be prevented by vitamin E supplementation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Ascorbic Acid / blood
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Dietary Supplements
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Gene Expression Regulation
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Haptoglobins / genetics*
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Humans
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Lipid Metabolism / genetics*
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Polymorphism, Genetic*
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Vitamin E / blood
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Vitamin E / metabolism
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Vitamin E / therapeutic use*
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Vitamin E Deficiency / drug therapy*
Substances
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HP protein, human
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Haptoglobins
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Vitamin E
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Ascorbic Acid