Association of the BDNF Val66Met variation with obesity in women

Sigri Beckers; Armand Peeters; Doreen Zegers; Ilse Mertens; Luc Van Gaal; Wim Van Hul

doi:10.1016/j.ymgme.2008.06.008

Association of the BDNF Val66Met variation with obesity in women

Mol Genet Metab. 2008 Sep-Oct;95(1-2):110-2. doi: 10.1016/j.ymgme.2008.06.008. Epub 2008 Jul 29.

Authors

Sigri Beckers¹, Armand Peeters, Doreen Zegers, Ilse Mertens, Luc Van Gaal, Wim Van Hul

Affiliation

¹ Department of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium. sigri.beckers@ua.ac.be

PMID: 18667348
DOI: 10.1016/j.ymgme.2008.06.008

Abstract

Brain-derived neurotrophic factor (BDNF) has been implied in the regulation of food intake. In the present study, we genotyped the Val66Met polymorphism in a Belgian cohort of 532 obese women and 197 healthy female controls and were, for the first time, able to show an association of the 66Met allele with obesity, at least in our female cohort.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Belgium
Brain-Derived Neurotrophic Factor / genetics*
Case-Control Studies
Cohort Studies
Female
Genetic Predisposition to Disease
Genetic Variation
Humans
Middle Aged
Mutation, Missense*
Obesity / genetics*
Polymorphism, Genetic
White People / genetics

Substances

Brain-Derived Neurotrophic Factor