Myocardial infarction and arterial thrombosis in identical newborn twins with homozygosity for the PAI-1 4 G/5 G polymorphism

Vittoria De Lucia; Maria Grazia Andreassi; Laura Sabatini; Lamia Ait-Ali; Isabella Spadoni; Sandra Giusti

doi:10.1016/j.ijcard.2008.05.030

Myocardial infarction and arterial thrombosis in identical newborn twins with homozygosity for the PAI-1 4 G/5 G polymorphism

Int J Cardiol. 2009 Sep 11;137(1):e1-4. doi: 10.1016/j.ijcard.2008.05.030. Epub 2008 Aug 13.

Authors

Vittoria De Lucia, Maria Grazia Andreassi, Laura Sabatini, Lamia Ait-Ali, Isabella Spadoni, Sandra Giusti

PMID: 18703246
DOI: 10.1016/j.ijcard.2008.05.030

Abstract

Myocardial infarction in the perinatal period, in the absence of congenital heart disease or coronary artery lesions, is rare. The most common etiology described are the thromboembolism and perinatal asphyxia. We report a case of monozygotic twins who developed, after birth, acute vascular events and both had PAI-1 4G/4G homozygosity.

Publication types

Case Reports
Letter

MeSH terms

Adult
Diseases in Twins / diagnosis
Diseases in Twins / genetics*
Female
Follow-Up Studies
Homozygote
Humans
Infant, Newborn
Male
Myocardial Infarction / diagnosis
Myocardial Infarction / genetics*
Plasminogen Activator Inhibitor 1 / genetics*
Polymorphism, Genetic / genetics*
Thrombosis / diagnosis
Thrombosis / genetics*
Twins, Monozygotic / genetics*

Substances

Plasminogen Activator Inhibitor 1
SERPINE1 protein, human