Abstract
A 13-year-old girl developed bilateral chronic anterior uveitis following bacille Calmette-Guérin (BCG) vaccination. HLA testing was negative for B27 but positive for DRB1 *0404, a variant of DR4 often associated with rheumatoid arthritis. The authors propose her HLA repertoire allowed for a BCG-induced abnormal autoimmune response by the mechanism of molecular mimicry.
MeSH terms
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Adolescent
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Alleles
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BCG Vaccine / adverse effects*
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Chronic Disease
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Female
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Functional Laterality
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HLA-DR Antigens / genetics
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HLA-DRB1 Chains
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Humans
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Molecular Mimicry / genetics*
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Polymerase Chain Reaction
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Tuberculosis / prevention & control
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Uveitis, Anterior / etiology*
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Uveitis, Anterior / genetics
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Vaccination
Substances
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BCG Vaccine
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HLA DRB1*04:04 antigen
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HLA-DR Antigens
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HLA-DRB1 Chains