Abstract
Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antigens, Nuclear / genetics*
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DNA-Binding Proteins / genetics*
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Down-Regulation
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Female
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Humans
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Hypoxia / genetics*
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Immunoenzyme Techniques
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Ku Autoantigen
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Middle Aged
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Prospective Studies
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Uterine Cervical Neoplasms / genetics*
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Uterine Cervical Neoplasms / radiotherapy
Substances
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Antigens, Nuclear
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DNA-Binding Proteins
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Xrcc6 protein, human
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Ku Autoantigen