Abstract
We report the psychopathological features in a large Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene. Of the 23 living family members, 14 were evaluated using the Structured Clinical Interview for DSM-IV, the Yale-Brown Obsessive-Compulsive Scale, the Clinical Global Impression and the Global Assessment of Functioning scale. Ten patients were found to have obsessive-compulsive disorder in which tic-like compulsions predominated. The distinctive feature of this family is the high frequency of obsessive-compulsive disorder with various clinical phenotypes.
MeSH terms
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Adolescent
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Adult
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Age of Onset
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Child
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Cross-Sectional Studies
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Female
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Genetic Linkage / genetics*
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Genotype*
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Humans
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Italy
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Male
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Membrane Proteins / genetics*
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Middle Aged
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Nerve Tissue Proteins / genetics*
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Obsessive-Compulsive Disorder / epidemiology
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Obsessive-Compulsive Disorder / genetics*
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Obsessive-Compulsive Disorder / psychology*
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Personality Assessment / statistics & numerical data
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Phenotype
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Psychometrics
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Psychopathology
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Tourette Syndrome / epidemiology
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Tourette Syndrome / genetics*
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Tourette Syndrome / psychology*
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Young Adult
Substances
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Membrane Proteins
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Nerve Tissue Proteins
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SLITRK1 protein, human