Association of beta-fibrinogen gene -148C/T and -455G/A polymorphisms and coronary artery disease in Chinese population: a meta analysis

Sci China C Life Sci. 2008 Sep;51(9):814-20. doi: 10.1007/s11427-008-0102-0. Epub 2008 Aug 24.

Abstract

The purpose of our study was to evaluate the correlation between the beta-fibrinogen gene -148C/T and -455G/A polymorphisms and susceptibility to coronary artery disease in the Chinese population using a meta-analytic approach. Eligible studies about this correlation were identified by searching the PubMed, EMBASE, and CNKI databases. Of the 13 identified, 7 (with 1488 cases and 1234 controls) involved the -148C/T polymorphism and 9 (with 1023 cases and 1081 controls) involved the -455G/A polymorphism. No publication bias was detectable and heterogeneity testing found significant differences between the ORs for both groups of studies. The combined OR for the 7 studies on susceptibility to coronary artery disease in -148T allele carriers compared to the -148C/C wild-type homozygotes was 1.31 (95%CI: 0.94-1.84, P = 0.11). The combined OR for the 9 studies on susceptibility to coronary artery disease in -455A allele carriers compared to the -455G/G wild-type homozygotes was 1.75 (95%CI: 1.24-2.46, P = 0.001). Our results suggest the absence of an association between the beta-fibrinogen gene -148C/T polymorphism and susceptibility to coronary artery disease and the possibility that -455G/A polymorphism (in particular, allele A) increases susceptibility to this disease in the Chinese population.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian People / genetics*
  • Coronary Artery Disease / genetics*
  • Fibrinogen / chemistry
  • Fibrinogen / genetics*
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Protein Isoforms / chemistry
  • Protein Isoforms / genetics

Substances

  • BBeta fibrinogen
  • Protein Isoforms
  • Fibrinogen