Maternal serum mannose-binding lectin in severe preeclampsia

Clin Exp Obstet Gynecol. 2008;35(3):179-82.

Abstract

Purpose: We aimed to investigate the level of serum mannose-binding lectin (MBL) in severe preeclamptic patients, women with uncomplicated pregnancies, and healthy reproductive-age females and its impact on gestational age at delivery and birth weight.

Methods: Serum MBL levels were measured in 27 severe preeclampsia patients (Group 1), 27 patients with uncomplicated pregnancies (Group 2), and 25 healthy reproductive-age women (Group 3).

Results: The mean serum MBL was significantly higher (p < or = 0.05) in Group 1 than in Groups 2 and 3, while the levels in Groups 2 and 3 did not significantly differ. The mean gestational age at delivery and mean birth weight were significantly lower in Group 1. In Group 1, serum MBL was negatively correlated (p < or = 0.05) with the gestational age at delivery and birth weight.

Conclusion: Serum MBL increased in preeclampsia and was negatively correlated with the gestational age at birth and birth weight, indicating an underlying immunopathogenesis.

MeSH terms

  • Adult
  • Birth Weight
  • Case-Control Studies
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Male
  • Mannose-Binding Lectin / blood*
  • Pre-Eclampsia / blood*
  • Pregnancy

Substances

  • Mannose-Binding Lectin