Lack of association between MTHFR C677T and MTHFR A1298C genetic polymorphisms and mental retardation

Patrizia Saccucci; Eliana Compagnone; Alberto Verrotti; Cinzia Galasso; Paolo Curatolo

doi:10.1179/147683008X301595

Lack of association between MTHFR C677T and MTHFR A1298C genetic polymorphisms and mental retardation

Nutr Neurosci. 2008 Oct;11(5):241-2. doi: 10.1179/147683008X301595.

Authors

Patrizia Saccucci¹, Eliana Compagnone, Alberto Verrotti, Cinzia Galasso, Paolo Curatolo

Affiliation

¹ Division of Human Population and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy. saccucci@med.uniroma2.it

PMID: 18782485
DOI: 10.1179/147683008X301595

Abstract

Findings suggest that there is no association between MTHFR C677T and MTHFR A1298C and mental retardation in the studied Italian population and that these polymorphisms are not contributing to the aetiology of mental retardation.

MeSH terms

Adolescent
Child
Child, Preschool
Genetic Predisposition to Disease
Humans
Intellectual Disability / enzymology
Intellectual Disability / genetics*
Italy
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Polymerase Chain Reaction
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length

Substances

Methylenetetrahydrofolate Reductase (NADPH2)