Abstract
At the FASEB summer research conference on "Arf Family GTPases", held in Il Ciocco, Italy in June, 2007, it became evident to researchers that our understanding of the family of Arf GTPase activating proteins (ArfGAPs) has grown exponentially in recent years. A common nomenclature for these genes and proteins will facilitate discovery of biological functions and possible connections to pathogenesis. Nearly 100 researchers were contacted to generate a consensus nomenclature for human ArfGAPs. This article describes the resulting consensus nomenclature and provides a brief description of each of the 10 subfamilies of 31 human genes encoding proteins containing the ArfGAP domain.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ADP-Ribosylation Factors / chemistry
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ADP-Ribosylation Factors / genetics
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ADP-Ribosylation Factors / metabolism*
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism
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Animals
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Cytoskeletal Proteins / genetics
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Cytoskeletal Proteins / metabolism
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GTPase-Activating Proteins / chemistry
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GTPase-Activating Proteins / genetics
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GTPase-Activating Proteins / metabolism*
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Humans
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Microtubule-Associated Proteins / genetics
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Microtubule-Associated Proteins / metabolism
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Models, Molecular
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Molecular Sequence Data
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Multigene Family
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Protein Conformation
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Terminology as Topic*
Substances
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ACAP1 protein, human
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AGAP1 protein, human
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Adaptor Proteins, Signal Transducing
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Cell Cycle Proteins
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Cytoskeletal Proteins
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FYB1 protein, human
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GIT1 protein, human
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GTPase-Activating Proteins
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KIFAP3 protein, human
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MAP9 protein, human
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Microtubule-Associated Proteins
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ADP-Ribosylation Factors