Purpose: To report a case of Acanthamoeba keratitis clinically presenting with a plaque-like lesion typical of fungal keratitis.
Methods: A 55-year-old woman presented with a yellow plaque-like lesion on the cornea surrounded by an infiltrate. Smears and culture were taken. The plaque was removed and subjected to histopathological investigation.
Results: Smear, culture, and histopathology results confirmed Acanthamoeba (cysts). The patient was treated with intensive topical medication. The infection resolved after 8 weeks of treatment.
Conclusions: Acanthamoeba infection of cornea may present as a plaque-like lesion. In addition to topical medication, plaque removal helps in early resolution of the infection.